PD-1 Antibody

SKU: orb3127245

Description

PD-1 is expressed on the surface of activated T cells, B cells and myeloid cells. PD-1 has two natural ligands, PD-L1 and PD-L2. Engagement of PD-1 with either ligand suppresses immune responses and promotes self-tolerance. PD-L1 and PD-L2 only share 37% sequence identity, but have similar functions and expression profiles. Where PD-L1 is expressed in immune cells such as T and B cells, DCs, and macrophages, as well as in many different tumor types. PD-L2 expression has been reported to be more restricted to APCs. The overexpression of PD-L1 and/or PD-L2 in cancer cells reduces the body’s immune responses, enabling cancer cells to evade killing mediated by T cells. PD-L1 is expressed more widely by tumor cells than PD-L2, and the blockade of the PD-1/PD-L1 interaction is more frequently targeted by therapeutic agents . RMP1-14 is a monoclonal antibody that targets the murine PD-1 protein , and has been used extensively to probe the effects of PD-1 inhibition in preclinical murine models .

Images & Validation

• Reactivity: Mouse
• Application Notes:
  Recomended Isotype: Rat IgG2a Isotype control, Recomended Isotype Catalog: orb3127217

Key Properties

• Antibody Type: Primary Antibody
• Host: Rat
• Clonality: Monoclonal
• Isotype: Rat IgG2a k
• Clone No.: RMP1-14
• Immunogen: Mouse PD-1 transfected BHK cells
• Target: PD-1
• Purity: ≥ 90 % (CGE, reducing conditions) ≤ 10 % aggregates (analytical SEC) Endotoxin level ≤ 2 EU/mg
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Form/Appearance: Clear Liquid, PBS, pH 7.4, 0.2 μm sterile filtered
• Concentration: ≥ 1 mg/ mL
• Disclaimer: For research use only

Alternative Names

PD-1, anti-mouse PD1, CD279, programmmed cell death protein 1, Protein PD-1, mPD-1, RMP1-14.

Quick Database Links

Gene Symbol

PD-1

UniProt

Q02242