PCL 016

SKU: orb1302514

Description

PCL 016 (2-Picolinic acid) is a small-molecule antiviral compound that suppresses adenovirus replication. It is utilized in virology and antiviral research, with studies demonstrating its inhibitory activity in both in vitro assays and in vivo rabbit models of adenovirus infection.

Research Area

Infectious Disease & Virology, Metabolism Research

Key Properties

• CAS Number: 98-98-6
• MW: 123.11
• Purity: 99.96% (May vary between batches)
• Formula: C₆H₅NO₂
• SMILES: OC(=O)C1=NC=CC=C1
• Target: Virus Protease,Endogenous Metabolite
• Solubility: DMSO:50 mg/mL (406.14 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (16.25 mM);H2O:50 mg/mL (406.14 mM)

Bioactivity

• In Vitro:
  Topical 1.5% PCL, 0.8% PCL, 0.369% PCL (pH7), 0.369% PCL (pH4) and 0.5% CDV are significantly more effective than the Control in reducing Ad Positive Cultures/Total (Days 1-14) and the Duration of Ad Shedding in the Ad5/NZW rabbit ocular model. Although not statistically significant, there appears to be a trend toward concentration-dependent efficacy of PCL 016 on the Duration of Ad Shedding. There is no apparent ocular toxicity associated with PCL 016 concentrations.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

2-Picolinic acid, PCL 016, PCL016, PCL-016, inhibit, Endogenous Metabolite, EndogenousMetabolite, Inhibitor, VirusProtease, Virus Protease

Compound Identifiers

PubChem CID

1018