2-Picolinic acid

SKU: orb1221403

Description

PCL 016 is a topical antiviral agent which inhibits adenovirus replication in rabbit.(In Vivo):Topical 1.5% PCL, 0.8% PCL, 0.369% PCL (pH7), 0.369% PCL (pH4) and 0.5% CDV are significantly more effective than the Control in reducing Ad Positive Cultures/Total (Days 1-14) and the Duration of Ad Shedding in the Ad5/NZW rabbit ocular model. Although not statistically significant, there appears to be a trend toward concentration-dependent efficacy of Picolinic acid on the Duration of Ad Shedding. There is no apparent ocular toxicity associated with Picolinic acid concentrations.

Key Properties

• CAS Number: 98-98-6
• MW: 123.11
• Purity: >98% (HPLC)
• Formula: C₆H₅NO₂
• SMILES: OC(=O)c1ccccn1
• Target: Endogenous Metabolite
• Solubility: DMSO:10 mM;Water:50 mg/mL

Bioactivity

• In Vivo:
  Topical 1.5% PCL, 0.8% PCL, 0.369% PCL (pH7), 0.369% PCL (pH4) and 0.5% CDV are significantly more effective than the Control in reducing Ad Positive Cultures/Total (Days 1-14) and the Duration of Ad Shedding in the Ad5/NZW rabbit ocular model. Although not statistically significant, there appears to be a trend toward concentration-dependent efficacy of Picolinic acid on the Duration of Ad Shedding. There is no apparent ocular toxicity associated with Picolinic acid concentrations.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PCL 016

Quick Database Links

Gene Symbol

Endogenous Metabolite