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PBRM1-BD2-IN-8

SKU: orb2900891

Description

PBRM1-BD2-IN-8 (compound 34) is a potent PBRM1 Bromodomain inhibitor (PBRM1-BD2 Kd=4.4 μM, PBRM1-BD2 IC50=0.16 μM; PBRM1-BD5 Kd=25 μM). PBRM1-BD2-IN-8 shows anti-cancer activity.

Research Area

Epigenetics & Chromatin

Images & Validation

Key Properties

CAS Number2819989-75-6
MW317.18
Purity>98% (HPLC)
FormulaC15H13BrN2O
SMILESO=C1C=2C(NC(N1)C3=CC(C)=CC=C3)=CC=CC2Br
TargetEpigenetic Reader Domain
SolubilityIn Vitro: DMSO : 100 mg/mL (315.28 mM; Ultrasonic )

Bioactivity

In Vitro
PBRM1-BD2-IN-8 (0-100 μM; 48 h) inhibits the growth of PBRM1-dependent prostate cancer cells. Cell Viability Assay Cell line: LNCaP cells. Concentration: 0-100 μM. Incubation time: 48 hours. Result: Inhibited the growth of LNCaP cells with IC50 value of about 9 μM.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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  • PBRM1-BD2-IN-8 [orb1689800]

    99.89% (May vary between batches)

    2819989-75-6

    317.18

    C15H13BrN2O

    100 mg, 1 mg, 5 mg, 10 mg, 25 mg, 50 mg, 1 ml x 10 mM (in DMSO)
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Protocol Information

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2 mg
$ 240.00
5 mg
$ 380.00
10 mg
$ 540.00
25 mg
$ 800.00
50 mg
$ 1,060.00
100 mg
$ 1,410.00
500 mg
$ 2,810.00