PBRM1-BD2-IN-8

SKU: orb1689800

Description

PBRM1-BD2-IN-8 (compound 34) is a selective inhibitor of the PBRM1 bromodomain 2 (BD2), exhibiting potent binding affinity (Kd=4.4 µM) and inhibitory activity (IC50=0.16 µM). This small molecule demonstrates anti-cancer properties in research settings, enabling the study of chromatin remodeling and gene regulation in both cellular and biochemical assays.

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 2819989-75-6
• MW: 317.18
• Purity: 99.89% (May vary between batches)
• Formula: C₁₅H₁₃BrN₂O
• SMILES: O=C1C=2C(NC(N1)C3=CC(C)=CC=C3)=CC=CC2Br
• Target: Epigenetic Reader Domain
• Solubility: DMSO:55 mg/mL (173.4 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.31 mM)

Bioactivity

• In Vitro:
  PBRM1-BD2-IN-8 (0-100 μM; 48 h) inhibits the growth of PBRM1-dependent prostate cancer cells.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

EpigeneticReaderDomain, Epigenetic Reader Domain, PBRM1BD2IN8, PBRM1-BD2-IN-8

Compound Identifiers

PubChem CID

164880766