PBD-monoamide

SKU: orb2564987

Description

PBD-monoamide is a pyrrolobenzodiazepine dimer derivative used as a cytotoxin in antibody-drug conjugates (ADCs), such as the HER2-targeting agent DHES0815A. Its mechanism involves sequence-selective DNA binding and crosslinking, leading to potent cytotoxicity in both in vitro cell viability assays and in vivo tumor models.

Key Properties

• CAS Number: 2093165-00-3
• MW: 616.66
• Formula: C₃₃H₃₆N₄O₈
• SMILES: O=C1C=2C(=CC(OCCCCCOC3=C(OC)C=C4C(=C3)N=C[C@]5(N(C4=O)CC(=C)C5)[H])=C(OC)C2)NC(=O)[C@]6(N1CC(=C)C6)[H]
• Target: ADC Cytotoxin

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

126757595