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DNA Alkylator/Crosslinker,EGFR Antibody

SKU: orb3031943

Description

MHES0488A is a selective humanized antibody targeting HER2, with a KD value of 0.8 nM. It constitutes the antibody portion of DHES0815A. Upon cellular internalization, MHES0488A is transported to lysosomes, releasing PBD-monoamide into the nucleus, where it alkylates DNA, inducing DNA damage and apoptosis. It shows potential for research in cancers such as HER2-positive breast cancer and gastric cancer.

Research Area

Cardiovascular Research, Cell Biology, Molecular Biology, Signal Transduction

Images & Validation

Key Properties

Antibody TypeInhibitor Antibody
TargetDNA Alkylator/Crosslinker,EGFR
ConjugationUnconjugated

Storage & Handling

StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information

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