PAX6 Rabbit mAb [KD Validated] Antibody

SKU: orb1951361

Description

Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes.

Images & Validation

• Tested Applications: ICC, IHC, WB
• Dilution Range: WB 1:500~1:1000 IHC 1:50~1:200 ICC/IF 1:50~1:200
• Reactivity: Human, Mouse, Rat

Key Properties

• Antibody Type: Recombinant Antibody
• Host: Rabbit
• Clonality: Monoclonal
• Isotype: Rabbit IgG
• Immunogen: A synthesized peptide derived from human PAX6
• Purification: Affinity-chromatography
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Form/Appearance: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Paired box protein Pax-6; Aniridia type II protein; Oculorhombin; PAX6; AN2;

All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.

Western blot analysis of PAX6 expression in Human brain lysate.

Quick Database Links

UniProt

P26367