PARK7 Rabbit mAb [KD Validated] Antibody

SKU: orb1951492

Description

Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking. It cooperates with Ras to increase cell transformation, it positively regulates transcription of the androgen receptor, and it may function as an indicator of oxidative stress.

Images & Validation

• Tested Applications: FC, ICC, IHC, IP, WB
• Dilution range: WB 1:1000~1:5000 IHC 1:50~1:200 ICC/IF 1:50~1:200 IP 1:20 FC 1:50
• Reactivity: Human, Mouse, Rat

Key Properties

• Antibody Type: Recombinant Antibody
• Host: Rabbit
• Clonality: Monoclonal
• Isotype: Rabbit IgG
• Immunogen: A synthesized peptide derived from human PARK7
• Purification: Affinity-chromatography
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Form/Appearance: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Disclaimer: For research use only

Alternative Names

Protein DJ-1; SP22; Protein DJ-1; Oncogene DJ1; Parkinson disease protein 7; PARK7;

All lanes use the Antibody at 1:2K dilution for 1 hour at room temperature.

Immunohistochemical analysis of paraffin-embedded human bladder cancer, using PARK7 Antibody.

Western blot analysis of PARK7 expression in HeLa cell lysate.

Quick Database Links

UniProt

Q99497