Paradol

SKU: orb1300060

Description

Paradol

Research Area

Immunology & Inflammation, Neuroscience

Key Properties

• CAS Number: 27113-22-0
• MW: 278.39
• Purity: 98.65%
• Formula: C₁₇H₂₆O₃
• SMILES: CCCCCCCC(=O)CCc1ccc(O)c(OC)c1
• Target: COX
• Solubility: DMSO:50 mg/mL (179.6 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.18 mM)

Bioactivity

• In Vivo:
  EAE-symptomatic mice were treated with 6-shogaol or 6-paradaol (5 mg/kg, p.o.) once daily for 14 days (between days 29 and 42 after immunization).Both 6-shogaol and 6-paradol significantly improved EAE-relevant symptoms fro the fourth day after drug administration (between days 32 and 42) except days 36 and 37 in the 6-paradol-treated EAE group compared to the Vehicle-treated EAE group (Fig. 1A, Supplementary Table 1) the effectiveness of 6-shogaol and 6-paradol was also clearly shown from cumulative clinical scores from days 30 to 43.Administration of 6-paradol or 6-shogaol significantly reduce the cumulative clinical score (6-shogaol, 25.25%;6-paradol, 25.75%) compared to the Vehicle-treated EAE group.6-shogaol and its metabolite, 6-paradaol, exert neur Protective effects against EAE.Moreover, these molecules are therapeutically effective for EA.
• Animal Research:
  MOG35-55 was emulsified in an equal amount of CFA. Mice were anesthetized with isoflurane and 200 μg of emulsion MOG35-55 in CFA was injected Subcutaneously a the start day of immunization (day 1). In addition, 400 ng of Bordetella pertussis toxin (PTX) per mouse was injected intraperitoneally o the start day of MOG immunization and 2 days later. Mice were weighed and monitored daily for clinical symptoms of EAE as follows: 0, no clinical signs of EAE; 0.5, some lack of tone, however, some strength a the base of tail; 1.0, total loss of tail tonicity and flaccid tail; 2.0, hind limb weakness; 2.5, incomplete paralysis of one or both hind limbs; 3.0, total paralysis of one or both hind limbs; 4.0, hind and fore limbs paralysis; 5.0, death from disease. For drug administration, symptomatic EAE mice were divided into three groups; (1 the Vehicle-treated EAE group, (2 the 6-shogaol-treated EAE group, and (3 the 6-paradol-treated EAE group. Vehicle (10% Tween 80), 6-shogaol (5 mg/kg), or 6-paradol (5 mg/kg) was orally administered daily into symptomatic EAE mice from day 29 to day 42 (for 13 days) post immunizatio.

Storage & Handling

• Storage: Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

Cyclooxygenase, COX-2, COX, [6]-Gingerone, [6]-Paradol, 6-paradol, Paradol, Inhibitor, inhibit

Compound Identifiers

PubChem CID

94378