6-paradol

SKU: orb1220603

Description

6-paradol is a pungent phenolic substance found in ginger and other Zingiberaceae plants and exhibits a variety of biological activities including anti-cancer anti-inflammatory and anti-oxidative activitiesneuroprotective Effects.

Key Properties

• CAS Number: 27113-22-0
• MW: 278.39
• Purity: >98% (HPLC)
• Formula: C₁₇H₂₆O₃
• SMILES: CCCCCCCC(=O)CCc1ccc(O)c(OC)c1
• Target: COX
• Solubility: DMSO:140 mg/mL (502.89 mM)

Bioactivity

• In Vivo:
  Administration of Paradol (6-paradol) (10 mg/kg) clearly reduces the number of Iba1-positive cells 1 and 3 days after the challenge. Moreover, Paradol dramatically reduces the number of Iba1-postive cells in periischemic regions even after 3 days following M/R challenge. Paradol (6-paradol) exhibits the strongest anti-inflammatory effect of several paradol compounds in lipopolysaccharide-stimulated BV2 microglia derived from a mouse brain, including 2-, 4-, 6-, 8-, and 10-paradol. Furthermore, Paradol shows the strongest pungency of all of the known paradol analogues. Paradol also shows the highest contact time at the antiobesity site of action on the basis of the results shown for the absorption of the metabolites in this study.
• In Vitro:
  Paradol (-paradol) induces apoptosis in an oral squamous carcinoma cell line, KB, in a dose-dependent manner. Paradol induces apoptosis through a caspase-3-dependent mechanism.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Paradol | [6]-Gingerone

Quick Database Links

Gene Symbol

COX