Pantoprazole sodium

SKU: orb1300337

Description

Pantoprazole sodium is a proton pump inhibitor prodrug that is activated in acidic parietal cell canaliculi. Its active sulfenamide metabolite irreversibly inhibits the H+/K+-ATPase enzyme, suppressing gastric acid secretion. This compound is widely used in research models for studying gastroesophageal reflux disease, peptic ulcers, and related in vivo and in vitro pharmacological mechanisms.

Research Area

Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Infectious Disease & Virology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 138786-67-1
• MW: 405.35
• Purity: 99.81% (May vary between batches)
• Formula: C₁₆H₁₄F₂N₃NaO₄S
• SMILES: [Na+].COc1ccnc(CS(=O)c2nc3cc(OC(F)F)ccc3[n-]2)c1OC
• Target: Autophagy,HIF,Antibacterial,Proton pump,Apoptosis
• Solubility: DMSO:55 mg/mL (135.69 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.93 mM);H2O:74 mg/mL (182.56 mM);Ethanol:75 mg/mL (185.03 mM)

Bioactivity

• In Vivo:
  After PPZ treatment, apoptotic cell death is seen selectively in cancer cells and is accompanied with extracellular signal-regulated kinase deactivation. By contrast, normal gastric mucosal cells show the resistance to PPZ-induced apoptosis through the overexpression of antiapoptotic regulators including HSP70 and HSP27. In a xenograft model of nude mice, administration of PPZ significantly inhibits tumorigenesis and induces large-scale apoptosis of tumor cells.
• In Vitro:
  pantoprazole (PPZ) inhibits tumor cells proliferation, inducs apoptosis and decreases the expression of HIF-1α protein. Pantoprazole affects the intracellular distribution of HIF-1α in SGC-7901 cells, which might be one of the mechanisms of its chemosensitizing effect on cancer cells.
• Cell Research:
  Pantoprazole sodium salts are resuspended in normal saline (0.85%) at 5 mg/ml immediately prior to use. When the SGC-7901 cells have reached 60–70% confluence, PPZ is added at a final concentration of 20 µg/ml, and the cells are cultured for additional experiments. For example, The SGC-7901 cells are seeded in 100 µl of medium per well, at a density of 1×104/well, in 96-well plates and treated with PPZ for 24 h. (Only for Reference)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Doxorubicin, BY 1023, BY1023, BY-1023, BY1023 (sodium), BY-1023 sodium, anti-secretory, anti-ulcer, Apoptosis, Autophagy, A431, MCF-7, Inhibitor, HIF-1α, exosome, H+/K+-ATPase, orally, Pantoloc, Pantoprazole, Pantoprazole sodium, Pantecta, inhibit, release, SKF 96022, SKF96022, SKF-96022, SKF96022 (sodium), SKF96022 sodium, stability, Protonpump, Proton Pump, Proton pump, pronton pump, PPI

Compound Identifiers

PubChem CID

15008962