Pantoprazole sodium

SKU: orb1226388

Description

A proton pump inhibitor that inhibits gastric acid secretion; works on gastric parietal cells to irreversibly inhibit (H+/K+)-ATPase function and suppress the production of gastric acid; inhibits autophagy and increases the toxicity of docetaxel in vitro and in vivo.Ulcer Approved(In Vitro):Pantoprazole sodium (BY1023 sodium; 1-10000 μM) leads to concentration-dependent increases in endosomal pH in EMT-6 and MCF7 cells.Pantoprazole sodium can block exosome release. Pantoprazole sodium inhibits the activity of V-H+-ATPase and impaires the ability of tumour cells (melanomas, adenocarcinomas, and lymphoma cell lines) to acidify the extracellular medium(In Vivo):Pantoprazole sodium (BY1023 sodium; 200 mg/kg; IP; once a week for 3 weeks) significantly increases tumor growth delay of MCF-7 xenografts combined with Doxorubicin.Pantoprazole sodium (0.3-3 mg/kg, p.o.) dose-dependently decreases both basal acid secretion in pylorus-ligated rats and the stimulated acid secretion induced by mepirizole in acute fistula rats.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 138786-67-1
• MW: 405.3516
• Purity: >98% (HPLC)
• Formula: C₁₆H₁₄F₂N₃NaO₄S
• SMILES: COC1=C(C(=NC=C1)CS(=O)C2=NC3=C([N-]2)C=CC(=C3)OC(F)F)OC.[Na+]
• Target: Proton Pump
• Solubility: H2O: ≥ 35 mg/mL

Bioactivity

• In Vivo:
  Pantoprazole sodium (BY1023 sodium; 200 mg/kg; IP; once a week for 3 weeks) significantly increases tumor growth delay of MCF-7 xenografts combined with Doxorubicin. Pantoprazole sodium (0.3-3 mg/kg, p.o.) dose-dependently decreases both basal acid secretion in pylorus-ligated rats and the stimulated acid secretion induced by mepirizole in acute fistula rats. Animal model: Mice bearing MCF-7 or A431 xenografts. Dosage: 200 mg/kg. Administration: IP; once a week for 3 weeks; alone or 2 hours before Doxorubicin (6 mg/kg i. v.). Result: Showed even greater growth delay of MCF-7 xenografts with Doxorubicin compared with the single-dose combination. Significantly increased tumor growth delay with a single dose with Doxorubicin.
• In Vitro:
  Pantoprazole sodium (BY1023 sodium; 1-10000 μM) leads to concentration-dependent increases in endosomal pH in EMT-6 and MCF7 cells. Pantoprazole sodium can block exosome release. Pantoprazole sodium inhibits the activity of V-H+-ATPase and impaires the ability of tumour cells (melanomas, adenocarcinomas, and lymphoma cell lines) to acidify the extracellular medium.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SKF-96022 sodium

Quick Database Links

Gene Symbol

Proton Pump