Panobacumab Antibody

SKU: orb1980688

Description

Panobacumab (KBPA101) is a fully human monoclonal antibody that binds to the O-polysaccharide of Pseudomonas aeruginosa LPS. It is used in research to study mechanisms against drug-resistant infections, demonstrating in vivo efficacy by enhancing bacterial clearance and reducing lung inflammation.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 885053-97-4
• MW: 146.09 kDa
• Purity: 95.00%
• Target: Antibacterial

Bioactivity

• In Vivo:
  Methods: Panobacumab (0.005-0.4 mg/kg, intravenous injection, single dose) was used to treat a BALB/c mouse model of acute lung infection and its therapeutic efficacy was observed. Results: Panobacumab rapidly eliminated P. aeruginosa from the lungs and completely eliminated systemic P. aeruginosa from the spleen, whereas untreated mice still had viable bacteria 48 hours after infection and had milder lung pathology at 6 and 24 hours after infection.
• In Vitro:
  Panobacumab (0.0001-100 ng/mL, 2 hours) specifically mediates complement-dependent phagocytosis of Pseudomonas aeruginosa serotype O11 with an IC50 of 0.16 ng/mL.

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

KBPA 101, KBPA101

Quick Database Links

Gene Symbol

Antibacterial