Pancuronium dibromide

SKU: orb1310878

Description

Pancuronium bromide is a potent competitive nicotinic acetylcholine receptor antagonist (IC50 = 5.5 nM) used as a neuromuscular blocking agent. It is widely applied in physiological research for skeletal muscle relaxation in vivo and for studying neuromuscular transmission mechanisms in vitro.

Research Area

Neuroscience

Key Properties

• CAS Number: 15500-66-0
• MW: 732.67
• Purity: 99.86%
• Formula: C₃₅H₆₀Br₂N₂O₄
• SMILES: [Br-].[Br-].[H][C@@]12C[C@@H]([C@H](OC(C)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC[C@@]2([H])C[C@H](OC(C)=O)[C@H](C[C@]12C)[N+]1(C)CCCCC1)[N+]1(C)CCCCC1
• Target: AChR
• Solubility: DMSO:60 mg/mL (81.89 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (2.73 mM);H2O:136.49 mM

Bioactivity

• Target IC50:
  AChR:5.5 nm
• In Vivo:
  Pancuronium decreases tidal volume (VT) and minute ventilation (VE) in high dosedogs by 82%. Pancuroniumdecreases tidal volume (VT) and minute ventilation (VE) in low dosedogs by 40% and 55%. Pancuronium limitscerebralhyperemia during prolongedseizuresby attenuating increases inbloodpressure as a result of elimination of skeletal muscle activity in newborn pigs. Pancuroniumresults in a significant difference with control is observed at gallamine concentrations ranging from 0.032-0.32 mM intrachealsmooth musclestrips fromguinea-pigs.
• In Vitro:
  Pancuronium results in open channel block of embryonic-type nicotinic acetylcholine receptor channels after coapplication of blocker and acetylcholine, characterized by decrease of the time constant of current decay. Pancuronium also results in competitive block of embryonic-type nicotinic acetylcholine receptor channels. Pancuronium increases heart rate, vecuronium and rocuronium produces positive inotropic effects, and vecuronium shortens refractoriness in isolated rat atria. Pancuronium (0.5 mM) induces a complete fade of the tetanic contraction while leaving the twitch unaffected in the extensor digitorum longus muscle of the rat. Pancuronium decreases the amplitude and increases the tetanic rundown of trains of endplate potentials (e.p.ps) evoked in the frequency of 50 Hz in the extensor digitorum longus muscle of the rat.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AChR, Nicotinic acetylcholine receptors, neuromuscular, nAChR, mAChR, Pancuronium, Pancuronium bromide, Pancuronium Bromide, Pancuronium Dibromide, Pancuronium dibromide, Pavulon, inhibit, noradrenaline, Inhibitor, sympathomimetic, Steroid, skeletal, relaxant

Compound Identifiers

PubChem CID

27350