Pancuronium bromide

SKU: orb1226111

Description

Pancuronium dibromide is a competitive AChR antagonist (IC50 = 5.5 nM) and acts as a skeletal muscle relaxant. Pancuronium dibromide interrupts neuromuscular transmission by competing with acetylcholine for receptor sites on the motor end-plate. (In Vitro):The action of Pancuronium on transmembrane sodium conductance is investigated in dorsal root ganglion neurones of chick embryos. Externally perfused Pancuronium (50 μM to 1 mM) reversibly inhibits the current by a fast mechanism of action. Inhibition is concentration-dependent (with a half-effective dose of 170 μM) but not voltage-dependent. Pancuronium may reduce the sodium current by interacting with the sodium channels in both the resting and open states.(In Vivo):Pancuronium (0.5 mg/kg; intravenous injection) abolishes the bradycardia induced both by injected acetylcholine (ACh) and by vagal nerve stimulation in guinea-pigs (250-300 g, male). At doses which produce 100% neuromuscular blockade, Pancuronium (0.04 mg/kg) potentiates vagally-induced bronchoconstriction.Potentiation by Pancuronium of the effects of adrenergic nerve stimulation, is found in rat anococcygeus and vas deferens.

Key Properties

• CAS Number: 15500-66-0
• MW: 732.67
• Purity: >98% (HPLC)
• Formula: C₃₅H₆₀Br₂N₂O₄
• SMILES: CC(=O)O[C@H]1C[C@@H]2CC[C@@H]3[C@@H]([C@]2(C[C@@H]1[N+]4(CCCCC4)C)C)CC[C@]5([C@H]3C[C@@H]([C@@H]5OC(=O)C)[N+]6(CCCCC6)C)C.[Br-].[Br-]
• Target: AChR
• Solubility: Very soluble in water

Bioactivity

• In Vivo:
  Pancuronium (0.5 mg/kg; intravenous injection) abolishes the bradycardia induced both by injected acetylcholine (ACh) and by vagal nerve stimulation in guinea-pigs (250-300 g, male). At doses which produce 100% neuromuscular blockade, Pancuronium (0.04 mg/kg) potentiates vagally-induced bronchoconstriction. Potentiation by Pancuronium of the effects of adrenergic nerve stimulation, is found in rat anococcygeus and vas deferens.
• In Vitro:
  The action of Pancuronium on transmembrane sodium conductance is investigated in dorsal root ganglion neurones of chick embryos. Externally perfused Pancuronium (50 μM to 1 mM) reversibly inhibits the current by a fast mechanism of action. Inhibition is concentration-dependent (with a half-effective dose of 170 μM) but not voltage-dependent. Pancuronium may reduce the sodium current by interacting with the sodium channels in both the resting and open states.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NSC 293162

Quick Database Links

Gene Symbol

AChR