Pamidronate Disodium

SKU: orb1308932

Description

Pamidronate Disodium (CGP 23339A) is a nitrogen-containing bisphosphonate used in research to investigate bone metabolism. It is applied in in vitro and in vivo studies for its osteoclast-inhibiting properties, which help to increase bone mineral density and strength.

Research Area

Immunology & Inflammation, Infectious Disease & Virology, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 57248-88-1
• MW: 279.03
• Purity: 99.94% (May vary between batches)
• Formula: C₃H₉NNa₂O₇P₂
• SMILES: [Na+].[Na+].NCCC(O)(P(O)([O-])=O)P(O)([O-])=O
• Target: HBV,Wnt/beta-catenin,Antibacterial,RANKL/RANK,TLR
• Solubility: DMSO:Insoluble;H2O:10 mM

Bioactivity

• In Vivo:
  In human osteoblast-like cells, Pamidronate (1 μM) enhances the level of OPG mRNA and protein secretion in a dose-dependent manner. Additionally, in mouse osteoclast-like cells (IC50=0.58 μM), Pamidronate inhibits the resorption of calcium phosphate films.
• In Vitro:
  In ovariectomized rats, Pamidronate significantly enhanced bone density and trabecular weight. Additionally, in rats treated with Growth Hormone (GH), Pamidronate reduced the levels of IGF-I.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CGP 23339A, CGP 23339AE, HAP, FPPS, Pamidronate, Pamidronate Disodium, Pamidronate disodium salt

Compound Identifiers

PubChem CID

73351