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Catalog Number | orb1686464 |
---|---|
Category | Small Molecules |
Description | Palbociclib hydrochloride |
CAS Number | 571189-11-2 |
Purity | 98.00% |
MW | 514.99 |
SMILES | Cl.O=C1C(C(=O)C)=C(C=2C=NC(=NC2N1C3CCCC3)NC4=NC=C(C=C4)N5CCNCC5)C |
Formula | C24H29N7O2.37/20ClH |
Biological Activity | Palbociclib (PD 0332991) hydrochloride is a selective and potent inhibitor of CDK4 (IC50: 11 nM) and CDK6 (IC50: 16 nM). Palbociclib hydrochloride has anti-proliferative effects on cancer cells and induces cell cycle arrest, and can be used in research on HR-positive and HER2-negative breast cancer, as well as hepatocellular carcinoma. |
Note | For research use only |
Expiration Date | 12 months from date of receipt. |
> 98% (HPLC) | |
827022-32-2 |
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