Verapamil hydrochloride

SKU: orb1310060

Description

Verapamil hydrochloride

Research Area

Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 152-11-4
• MW: 491.06
• Purity: 99.84%
• Formula: C₂₇H₃₉ClN₂O₄
• SMILES: Cl.COc1ccc(CCN(C)CCCC(C#N)(C(C)C)c2ccc(OC)c(OC)c2)cc1OC
• Target: Calcium Channel,Cytochromes P450,P-gp
• Solubility: H2O:24.6 mg/mL (50.1 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.07 mM);DMSO:86.67 mg/mL (176.5 mM)

Bioactivity

• In Vivo:
  Verapamil and Diltiazem essentially inhibit the hydrolase activity of recombinant CES2, with inhibition constants (Ki) of 0.25 ± 0.02 μM and 3.84 ± 0.99 μM, respectively.
• In Vitro:
  Verapamil exhibits antiarrhythmic properties, reduces myocardial oxygen consumption in rats, and preserves Cx43 protein.
• Cell Research:
  Verapamil is dissolved in DMSO and stored, and then diluted with appropriate media before use. Cells (1×105) are treated with 10 nM Bortezomib and/or 70 μM Verapamil for 16 hours and incubated for another 4 hours with Alamar-Blue. Activity of the mitochondrial dehydrogenase results in conversion of the coloring, which is followed by measurement of the absorption using a spectrophotometer.

Storage & Handling

• Storage: keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

(±)-Verapamil, (±)-Verapamil hydrochlorid, ABCB1, angina, antiarrhythmic, CalciumChannel, Calcium Channel, Ca2+ channels, Calcan hydrochloride, Calcan Hydrochloride, Ca channels, blood, CYP3A4, CYPs, Cytochrome P450, CD243, Cluster of differentiation 243, Palbociclib, Inhibitor, inhibit, Multidrug resistance protein 1, lysosomotropic, MDR1, Manidon, high, pressure, P-gp (P-glycoprotein), Pgp, P-gp, P-glycoprotein, Verapamil, Verapamil HCl, Verapamil hydrochlorid, Verapamil hydrochloride, Verapamil Hydrochloride

Compound Identifiers

PubChem CID

62969