Paederosidic acid

SKU: orb1220763

Description

Paederosidic acid has significant anti-tumor anticonvulsant and sedative effects. Paederosidic acid increases brain gamma-aminobutyric acid and decreases glutamic acid in the brain and it up-regulates expressions of GAD 65 may be a promising future therapeutic agent for treatment of epilepsy.

Key Properties

• CAS Number: 18842-98-3
• MW: 464.4
• Purity: >98% (HPLC)
• Formula: C₁₈H₂₄O₁₂S
• SMILES: [H][C@]12[C@@H](O)C=C(COC(=O)SC)[C@@]1([H])[C@H](O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)OC=C2C(O)=O
• Target: Bcl-2
• Solubility: In Vitro: DMSO : 100 mg/mL (215.31 mM)

Bioactivity

• In Vitro:
  Paederosidic acid (40 μg/ml; 24 hours and 48 hours) has no significant effect on BSAS-2B cells, it exhibits obvious effects on NCI-H1650, HCC827, A549 cells with IC50 values of40.68, 42.58, and 36.48 μg/ml, respectively. Paederosidic acid induces mitochondria-mediated apoptosis via up-regulation of caspase-3, caspase-8, caspase-9, Bid, Bax, down-regulation ofBcl-2 and stimulating the release of Cyto-C from mitochondria in lung cancer cells..

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Bcl-2