Pachymic acid

SKU: orb1300249

Description

Pachymic acid

Research Area

Signal Transduction

Key Properties

• CAS Number: 29070-92-6
• MW: 528.76
• Purity: 99.91% (May vary between batches)
• Formula: C₃₃H₅₂O₅
• SMILES: CC(C)C(=C)CC[C@H]([C@H]1[C@H](O)C[C@@]2(C)C3=C(CC[C@]12C)[C@@]1(C)CC[C@H](OC(C)=O)C(C)(C)[C@@H]1CC3)C(O)=O
• Target: Akt|||ERK
• Solubility: DMSO:9.52 mg/mL (18 mM)

Bioactivity

• In Vitro:
  Porinic acid (PA) exerted antitumor effects on NCI-H23 and NCI-H460 lung cancer cells in vitro, while inducing cellular G2/M phase arrest and apoptosis. Our data showed that PA induced reactive oxygen species (ROS) production, leading to activation of c-Jun N-terminal kinase (JNK) and endoplasmic reticulum (ER) stress apoptotic pathways in lung cancer cells. Furthermore, blocking ROS production reversed PA-induced JNK and ER stress activation. Finally, PA inhibited the growth of NCI-H23 xenograft tumors without causing any toxicity to the host, and suppressed cell proliferation and induced apoptosis in tumor xenograft tissues . At the same time, PA induced cell cycle arrest at G0 phase.PA also significantly inhibited cancer cell migration and invasion in a dose-dependent manner. Interestingly, PA inhibited the adhesion ability of cancer cells in a dose-dependent manner, which may contribute to the inhibition of cell invasion. Finally, it was shown that PA inhibited AKT and ERK signaling pathways. And tumor proteins such as PCNA, ICAM-1 and RhoA, which are involved in tumorigenesis, were also down-regulated by PA .
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• Cell Research:
  The anti-proliferative ability of PA on lung cancer cells was assessed by MTT, colony formation and EdU proliferation assays; cell cycle changes were detected by flow cytometry; apoptosis was detected by annexin V/PI double staining and DNA laddering; and the expression of apoptosis-related proteins was analyzed by Western blotting .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Akt, 3-O-Acetyltumulosic acid, inhibit, Pachymic acid, ERK, Extracellular signal regulated kinases, Inhibitor, Protein kinase B, PKB

Compound Identifiers

PubChem CID

5484385