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p53 Activator 7

SKU: orb1744677

Description

p53 Activator 7 is a potent, cell-permeable small molecule that selectively stabilizes and reactivates the p53 Y220C mutant protein, triggering apoptotic cell death. Its application in cancer research includes in vitro studies in mutant p53 cell lines and in vivo proof-of-concept models investigating tumor suppression.

Research Area

Cancer Biology, Cell Biology

Images & Validation

Key Properties

CAS Number2849340-59-4
MW516.538
Purity99.72% (May vary between batches)
FormulaC27H32F3N4OP
SMILESO=P(C1=CC=C(C=C1)NCC#CC2=CC=3C(=CC=CC3N2CC(F)(F)F)NC4CCN(C)CC4)(C)C
TargetMDM-2/p53,Apoptosis
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.39 mM);DMSO:80 mg/mL (154.88 mM)

Bioactivity

Target IC50
p53-Y220C:104 nM

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Apoptosis, MDM-2/p53

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

Protocol Information

Available Sizes

Select a size below

1 mg
$ 290.00
5 mg
$ 710.00
1 ml x 10 mM (in DMSO)
$ 800.00
10 mg
$ 1,110.00
25 mg
$ 1,630.00
50 mg
$ 2,190.00
DispatchUsually dispatched within 5-10 working days
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