NSC59984

SKU: orb1300354

Description

NSC59984

Research Area

Cell Biology

Key Properties

• CAS Number: 803647-40-7
• MW: 265.27
• Purity: 99.59%
• Formula: C₁₂H₁₅N₃O₄
• SMILES: CN1CCN(CC1)C(=O)\C=C\c1ccc(o1)[N+]([O-])=O
• Target: p53,MDM-2/p53
• Solubility: Ethanol:49 mg/mL (184.72 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:55 mg/mL (207.34 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.54 mM)

Bioactivity

• In Vivo:
  In nude mice bearing DLD-1 xenograft tumors, NSC59984 (45 mg/kg, i.p.) significantly represses tumor growth in a p73-dependent manner.
• In Vitro:
  NSC59984 selectively reactivate the p53 pathway and induces p73-dependent cell death in mutant p53-expressing human colorectal cancer cells. It also promotes cell death in various cancer cell lines with different p53 mutations, showing minimal genotoxicity in normal cells.
• Cell Research:
  Cells are seeded at 5,000 cells per well on 96-well plates. Cells are mixed with an equal volume of CellTiter-Glo reagents, followin the manufacturer's protocol, and bioluminescence imaging is measured usin the IVIS imager.(Only for Reference)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

NSC 59984, p53, NSC59984, NSC-59984, Inhibitor, inhibit, MDM-2/p53

Compound Identifiers

PubChem CID

5356520