p38-α MAPK-IN-1

SKU: orb1309286

Description

p38-α MAPK-IN-1 is a selective inhibitor of the MAPK14 (p38-α) kinase, demonstrating IC50 values of 2.3 µM and 5.5 µM in biochemical EFC and HTRF assays, respectively. This compound is a valuable research tool for investigating p38-α signaling pathways in cellular models of inflammation, stress response, and related diseases.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 443913-15-3
• MW: 477.6
• Purity: 99.93%
• Formula: C₂₇H₃₅N₅O₃
• SMILES: Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCCN2CCOCC2)cc1)C(C)(C)C
• Target: Autophagy,p38 MAPK
• Solubility: H2O:insoluble;10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (8.38 mM);DMSO:100 mg/mL (209.38 mM)

Bioactivity

• Target IC50:
  p38α:2300 nM in EFC assay|p38α:5500 nM in HTRF assay
• In Vitro:
  p38-α MAPK-IN-1 is a MAPK14 (p38-α) inhibitor(IC50 of 2300 nM, in EFC displacement assay, and 5500 nM in HTRF assay).

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Autophagy, Inhibitor, inhibit, p38 MAPK, p38MAPK, p38-alpha MAPK-IN-1, p38-a MAPK-IN-1, p38 α MAPK IN 1, p38α MAPKIN1, p38α, p-38-α MAPK-IN-1, p38-α MAPK-IN-1

Compound Identifiers

PubChem CID

10972838