BChE/p38-α MAPK-IN-1

SKU: orb3173069

Description

BChE/p38-α MAPK-IN-1 is a selective dual inhibitor targeting hBChE (IC50 = 772 nM) and p38α MAPK (IC50 = 191 nM). It reduces the production of pro-inflammatory cytokines (IL-1β, IL-6, IL-8, TNF-α) in cells, improves scopolamine-induced cognitive impairment, alleviates LPS-induced spatial learning deficits, and exhibits anti-neuroinflammatory effects in mice, making it applicable for Alzheimer's disease (AD) research.

Research Area

Immunology & Inflammation, Neuroscience, Signal Transduction

Key Properties

• CAS Number: 3077831-11-6
• MW: 454.57
• Formula: C₂₆H₃₂F₂N₄O
• SMILES: O=C(NCCN(C)C)C1=CC2=C(C=NN2CC3CCCCC3)C=C1CC4=CC=C(F)C=C4F
• Target: Interleukin,Cholinesterase (ChE),p38 MAPK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Interleukin,Cholinesterase (ChE),p38 MAPK