p-MPPF

SKU: orb2567327

Description

p-MPPF is a selective serotonin (5-HT) receptor antagonist. It dose-dependently blocks 8-OH-DPAT-induced hypothermia, making it a valuable pharmacological tool for investigating 5-HT system function in neurological disease models, both in vitro and in vivo.

Research Area

Cell Biology, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 155204-26-5
• MW: 434.51
• Purity: 99.93% (May vary between batches)
• Formula: C₂₅H₂₇FN₄O₂
• SMILES: O=C(C1=CC=C(F)C=C1)N(C2=NC=CC=C2)CCN3CCN(C=4C=CC=CC4OC)CC3
• Target: PERK,5-HT Receptor

Bioactivity

• In Vitro:
  The 5-HT(1A) receptor agonist 8-hydroxy-N,N-dipropionylaminotetralin (8-OH-DPAT) dose- and time-dependently reduced the basal levels of phosphorylated Erk1/2 (phospho-Erk1/2) in the rat hippocampus without changing total Erk/2, and pretreatment with p-MPPF blocked the effects of 8-OH-DPAT.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

pMPPF(155204265Freebase), 5-HT, 5HTReceptor, 5HT Receptor

Compound Identifiers

PubChem CID

6603915