p-MPPF dihydrochloride

SKU: orb1739730

Description

p-MPPF dihydrochloride is a selective 5-HT1A receptor antagonist, effectively countering 8-OH-DPAT-induced hypothermia in vivo. It is a valuable pharmacological tool for investigating serotonin-related neurological disorders in both in vitro and in vivo experimental models.

Research Area

Cell Biology, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 223699-41-0
• MW: 507.43
• Purity: 99.78% (May vary between batches)
• Formula: C₂₅H₂₉Cl₂FN₄O₂
• SMILES: O=C(N(CCN1CCN(CC1)C2=C(OC)C=CC=C2)C3=NC=CC=C3)C4=CC=C(C=C4)F.Cl.Cl
• Target: PERK,5-HT Receptor

Bioactivity

• In Vitro:
  The 5-HT(1A) receptor agonist 8-hydroxy-N,N-dipropionylaminotetralin (8-OH-DPAT) dose- and time-dependently reduced the basal levels of phosphorylated Erk1/2 (phospho-Erk1/2) in the rat hippocampus without changing total Erk/2, and pretreatment with p-MPPF dihydrochloride blocked the effects of 8-OH-DPAT.

Storage & Handling

• Storage: Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

5-HT, 5HTReceptor, 5HT Receptor, p-MPPF, p-MPPF Dihydrochloride, UK 356,202, UK 356202, UK356,202, UK-356,202, UK356202

Compound Identifiers

PubChem CID

11957633