Oxiconazole nitrate

SKU: orb1224369

Description

Oxiconazole nitrate (U.S.: Oxistat, Canada: Oxizole) is an antifungal medication typically administered in a cream or lotion to treat skin infections such as athlete's foot, jock itch and ringworm. (In Vitro):Oxiconazole (24 h; 0-40 μM) inhibits CRC cell growth.Oxiconazole has antifungal activity against Candida, Aspergillus and Trichophyton.(In Vivo):Oxiconazole (50 mg/kg/day; IP; for 12 days) significantly restrains CRC cell growth.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 64211-46-7
• MW: 492.14
• Purity: >98% (HPLC)
• Formula: C₁₈H₁₃Cl₄N₃O·HNO₃
• SMILES: C1=CC(=C(C=C1Cl)Cl)CO/N=C(\CN2C=CN=C2)/C3=C(C=C(C=C3)Cl)Cl.[N+](=O)(O)[O-]
• Target: Antifection
• Solubility: DMSO: 10 mM

Bioactivity

• In Vivo:
  Oxiconazole (50 mg/kg/day; IP; for 12 days) significantly restrains CRC cell growth. Animal model: BALB/c nude mice (injected subcutaneously with HCT116 cells (1×107/mouse). Dosage: 50 mg/kg/day. Administration: IP; for 12 days. Result: Significantly restrained CRC cell growth and showed no obvious side effects.
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• In Vitro:
  Oxiconazole (24 h; 0-40 μM) inhibits CRC cell growth. Oxiconazole has antifungal activity against Candida, Aspergillus and Trichophyton. Antifungal Activities of Oxiconazole. Cell Proliferation Assay Cell line: HCT116, SW480, RKO, DLD-1, SW620, LoVo and NCM460. Concentration: 0-40 μM. Incubation time: 24 h. Result: Exhibited inhibitory activity against HCT116, SW480, RKO, DLD-1, SW620, LoVo and NCM460 with IC50s of 25.86 μM, 27.34 μM, 21.01 μM, 25.56 μM, 21.75 μM, 24.87 μM and 126.4 μM.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Ro 13-8996

Quick Database Links

Gene Symbol

Antifection