Oxatomide

SKU: orb1705947

Description

Oxatomide is a potent oral dual antagonist of the H1 histamine and P2X7 receptors, exhibiting antiallergic activity. It is used in research to study immune diseases and hypersensitivity, effectively inhibiting ATP-induced currents (IC50 0.95 µM) and serotonin responses in experimental models.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Neuroscience, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 60607-34-3
• MW: 426.55
• Purity: 99.72% (May vary between batches)
• Formula: C₂₇H₃₀N₄O
• SMILES: O=C1NC2=C(C=CC=C2)N1CCCN1CCN(CC1)C(C1=CC=CC=C1)C1=CC=CC=C1
• Target: PERK,P2X Receptor,Histamine Receptor,COX,p38 MAPK,Apoptosis,5-HT Receptor,Calcium Channel
• Solubility: DMSO:170.62 mg/mL (400 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (9.38 mM)

Bioactivity

• In Vitro:
  Oxatomide almost completely blocks the ATP-induced current in human P2X7 receptors (IC50 of 0.95 μM). Oxatomide inhibits ATP-induced Ca2+ influx with an IC50 value of 0.43 μM and also inhibits serotonin.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Oxatomida, Oxatomide, P2X Receptor, P2X7, P2XReceptor, HistamineReceptor, Histamine Receptor, H1 receptor, CalciumChannel, Calcium Channel, Ca(2+) receptor, 5HT Receptor, 5HTReceptor, 5-HT Receptor

Compound Identifiers

PubChem CID

4615