Oxaprozin

SKU: orb1310364

Description

Oxaprozin is a nonsteroidal anti-inflammatory compound that acts as a cyclooxygenase inhibitor. It is used in research to study inflammation and pain mechanisms, with applications in both in vitro enzymatic assays and in vivo models of inflammatory disease.

Research Area

Cell Biology, Immunology & Inflammation, Neuroscience, Signal Transduction

Key Properties

• CAS Number: 21256-18-8
• MW: 293.32
• Purity: 99.02%
• Formula: C₁₈H₁₅NO₃
• SMILES: C(CC(O)=O)C1=NC(=C(O1)C2=CC=CC=C2)C3=CC=CC=C3
• Target: Apoptosis,IκB/IKK,COX,Akt,NF-κB
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.82 mM);Ethanol:26 mg/mL (88.64 mM);DMSO:55 mg/mL (187.51 mM)

Bioactivity

• Target IC50:
  COX-2:36 μM|COX-1:2.2 μM
• In Vivo:
  The anti-inflammatory effect of Oxaprozin is thought to be due to its inhibition of cyclooxygenases in platelets that block prostaglandin synthesis. This may be due to Oxaprozin's antipyretic effect on the hypothalamus, leading to an increase in peripheral blood flow, vasodilation, and subsequent heat dissipation.Oxaprozin has a lower selectivity for COX-2, implying a higher selectivity for COX-1.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Wy21743, Wy-21743, Wy 21743, PKB, Protein kinase B, I kappa B kinase, IKK, Inhibitor, Oxaprozinum, Oxaprozin, NFkB, NFκB, NF-kB, NF-κB, Nuclear factor-κB, Nuclear factor-kappaB, NSAID, IκB kinase, inhibit, COX, Cyclooxygenase, Apoptosis, anti-inflammatory, Akt

Compound Identifiers

PubChem CID

4614