Oxaprozin

SKU: orb1225676

Description

Oxaprozin is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID) used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis.(In Vitro):Oxaprozin induces apoptosis in a dose-dependent manner. Oxaprozin increases caspase-3 activity in the activated but not in the resting condition. NF-κB activation is inhibited by Oxaprozin (50 μM). Oxaprozin inhibits activation of the IKK system induced by the reagent IκBα.Oxaprozin (100 μM) induces the strongest proapoptotic effect and significantly increases CD40L-treated monocyte apoptosis. Oxaprozin treatment inhibits CD40L-induced Akt and NF-κB (p65) phosphorylation.

Key Properties

• CAS Number: 21256-18-8
• MW: 293.32
• Purity: >98% (HPLC)
• Formula: C₁₈H₁₅NO₃
• SMILES: CC1COC2=C3N1C=C(C(O)=O)C(C3=CC(F)=C2N4CCN(C)CC4)=O
• Target: COX
• Solubility: Ethanol: 27 mg/mL (92.04 mM); DMSO: 59 mg/mL (201.14 mM)

Bioactivity

• In Vitro:
  Oxaprozin induces apoptosis in a dose-dependent manner. Oxaprozin increases caspase-3 activity in the activated but not in the resting condition. NF-κB activation is inhibited by Oxaprozin (50 μM). Oxaprozin inhibits activation of the IKK system induced by the reagent IκBα. Oxaprozin (100 μM) induces the strongest proapoptotic effect and significantly increases CD40 L-treated monocyte apoptosis. Oxaprozin treatment inhibits CD40 L-induced Akt and NF-κB (p65) phosphorylation.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Daypro | NSC 310839 | Wy 21743

Quick Database Links

Gene Symbol

COX