Oxantel Pamoate

SKU: orb1310723

Description

Oxantel Pamoate is a small molecule anthelmintic agent used in research to study nematode infections. It is applied in both in vitro assays and in vivo animal models to investigate its selective cholinergic agonist activity against whipworms like Trichuris trichiura.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 68813-55-8
• MW: 604.65
• Purity: 99.89% (May vary between batches)
• Formula: C₃₆H₃₂N₂O₇
• SMILES: CN1CCCN=C1\C=C\c1cccc(O)c1.OC(=O)c1cc2ccccc2c(Cc2c(O)c(cc3ccccc23)C(O)=O)c1O
• Target: Parasite
• Solubility: DMSO:60 mg/mL (99.23 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.31 mM)

Bioactivity

• In Vivo:
  The efficacy of the veterinary drug Oxantel pamoate against Trichuris muris, Ancylostoma ceylanicum, and Necator americanus was evaluated, revealing an ED50s of 4.7 mg/kg for T. muris in mice. When combined with pyrantel pamoate, Oxantel pamoate showed an antagonistic interaction (CI=2.53). Similarly, combinations with Levamisole, Albendazole, or Ivermectin, based on their ED50s, also demonstrated antagonistic effects (CIs of 1.27, 1.90, and 1.27, respectively). Conversely, a combination with mebendazole exhibited a highly synergistic effect (CI=0.15) against T. muris infection. At a dosage of 10 mg/kg, Oxantel pamoate was ineffective against A. ceylanicum and N. americanus.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Antiparasitic, Oxantel embonate, Oxantel Pamoate, Oxantel, Parasite, inhibit, Inhibitor

Compound Identifiers

PubChem CID

5281086