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OX40 Antibody / CD134

Catalog Number: orb699522

DispatchUsually dispatched within 5-10 working days
$ 410.00
Catalog Numberorb699522
CategoryAntibodies
DescriptionThis MAb recognizes a protein of 43kDa, identified as OX40, which is also known as CD134.OX40 is a type I integral membrane glycoprotein and member of the tumor necrosis factor/nerve growth factor receptor (TNFR/NGFR) family. It is expressed on activated T lymphocytes, hematopoietic precursor cells and fibroblasts. It functions as a T cell co-stimulatory receptor when bound by OX40 Ligand / TNFSF4 that is expressed by antigen presenting cells. OX40 thereby plays roles in T-cell activation as well as the regulation of differentiation, proliferation or apoptosis of normal and malignant lymphoid cells.OX40 is upregulated at the sites of inflammation, especially in case of multiple sclerosis and psoriatic lesions.
ClonalityMonoclonal
Species/HostMouse
IsotypeMouse IgG1, kappa
ConjugationUnconjugated
ReactivityHuman
ImmunogenA portion of amino acids 59-205 from the human protein was used as the immunogen for the OX40 antibody.
UniProt IDP43489
Tested applicationsIHC-P
Dilution rangeImmunohistochemistry (FFPE): 1-2ug/ml for 30 minutes at RT
Application notesOptimal dilution of the OX40 antibody should be determined by the researcher.
Antibody TypePrimary Antibody
Clone NumberOX40/2721
Formula0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Hazard InformationThis OX40 antibody is available for research use only.
NoteFor research use only
OX40 Antibody / CD134

IHC staining of FFPE human lymph node with OX40 antibody. HIER: boil tissue sections in pH9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

OX40 Antibody / CD134

IHC staining of FFPE human lymph node with OX40 antibody. HIER: boil tissue sections in pH9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

OX40 Antibody / CD134

Analysis of HuProt (TM) microarray containing more than 19000 full-length human proteins using OX40 antibody. These results demonstrate the foremost specificity of the OX40/2721 mAb. Z- and S- score: The Z-score represents the strength of a signal that an antibody (in combination with a fluorescently-tagged anti-IgG secondary Ab) produces when binding to a particular protein on the HuProt (TM) array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If the targets on the HuProt (TM) are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-scores. The S-score therefore represents the relative target specificity of an Ab to its intended target.

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    Monoclonal

    Unconjugated

    20 μg, 100 μg
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    Mouse

    Monoclonal

    Unconjugated

    20 μg, 100 μg
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    FACS,  IF

    Mouse

    Rat

    Monoclonal

    Unconjugated

    20 μg, 100 μg