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Osunprotafib
Catalog Number: orb1688337
| Catalog Number | orb1688337 |
|---|---|
| Category | Small Molecules |
| Description | Osunprotafib (ABBV-CLS-484) is a potent, orally bioavailable inhibitor of PTP1B and PTPN2 currently in clinical trials for the treatment of solid tumors. It modulates the tumor microenvironment by boosting natural killer cell and CD8 T cell activity, enhancing anti-tumor immunity through activation of JAK–STAT signaling, and mitigating T cell dysfunction. |
| Target | PTPN2/PTPN1:0.176 μM (EC50), PTP1N:2.5 nM, PTP2N:1.8 nM |
| Form/Appearance | Powder |
| MW | 385.45 |
| Solubility (25°C) | DMSO: 56.2 mg/mL (145.9 mM), Sonication is recommended. H2O: < 1 mg/mL (insoluble) |
| CAS Number | 2489404-97-7 |
| Formula | C17H24FN3O4S |
| SMILES | CC(C)CCN[C@@H]1CCc2cc(O)c(N3CC(=O)NS3(=O)=O)c(F)c2C1 |
| Storage | Powder: -20°C |
| Alternative names | Osunprotafib, AC484, AC 484, ABBV-CLS-484 |
| Research Area | Metabolism Research |
| Note | For research use only |
| Expiration Date | 12 months from date of receipt. |
Cas No. 2489404-97-7
For example, if the dosage of your experiment is 10mg/kg, the weight of each animal is 50g, and the volume of the dosing is 100μL, then the working solution concentration of your experiment is 5mg/mL. If the formula you used is 5% DMSO+ 30% PEG300+ 5% Tween 80 + 60% Saline/PBS/ddH2O, the preparation method is as follows:
Mother liquor preparation method: 5mg of drug dissolved in 100μL DMSO (mother liquor concentration is 50mg/mL). Preparation method of in vivo formulation: For 1mL of working solution preparation, take 50μL of DMSO mother liquor, add 300 μL of PEG300 to mix well and clarify, then add 50μL of Tween-80 to mix well and clarify, and finally add 600μL of Saline/PBS/ddH2O to mix well and clarify.Note:
- For Reference Only. Please choose the appropriate dissolution protocol according to your experimental animal and administration method.
- We suggest that in cell experiments, the final concentration of DMSO is not more than 0.1%, in animal experiments, for healthy mice, the final concentration of DMSO is not more than 10%; For nude or frail mice, the final concentration of DMSO is not more than 2%.
