Osunprotafib hydrochloride

SKU: orb3135829

Description

Osunprotafib (ABBV-CLS-484) hydrochloride is an orally active, selective inhibitor targeting the active sites of PTPN1 (IC50: 2.5 nM) and PTPN2 (IC50: 1.8 nM). It shows 6-8 times weaker activity towards PTPN9 and no detectable activity against SHP-1 or SHP-2. This compound enhances the sensitivity of human cancer cell lines to IFNγ. By boosting JAK-STAT signaling and reducing T cell dysfunction, Osunprotafib hydrochloride exhibits potent antitumor immunity.

Research Area

Metabolism Research

Key Properties

• CAS Number: 2986745-48-4
• MW: 421.92
• Formula: C₁₇H₂₅ClFN₃O₄S
• SMILES: FC=1C(=C(O)C=C2C1C[C@H](NCCC(C)C)CC2)N3CC(=O)NS3(=O)=O.Cl
• Target: Phosphatase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Phosphatase