Oroxylin A

SKU: orb1222208

Description

Oroxylin A has various anti-tumor effects including apoptosis, cell cycle arrest, drug-resistant reversion. Oroxylin A possesses abilities of inhibiting the ATRA-induced IL-6 production via modulation of LAP/LIP/CHOP in leukemia cell lines, which could providing a therapeutic strategy for RAS. Oroxylin A inhibits UCP2s triggers the MPTP opening, and promotes the apoptosis in CaCo-2 cells; uncoupling protein 2 plays a key role in mitochondrial apoptotic pathway. Oroxylin A inhibits N1ICD translocating to the nucleus and binding to epithelial-mesenchymal transition-related transcription factor Snail, thus suppressing the invasion and migration of MCF-7 cells. Oroxylin A improves the sensitivity of K562/ADM cells by increasing apoptosis in leukemic cells and decreasing the expression of CXCR4 and PI3K/Akt/NF-κB pathway, and probably served as a most promising agent for CML treatment.

Key Properties

• CAS Number: 480-11-5
• MW: 284.26
• Purity: >98% (HPLC)
• Formula: C₁₆H₁₂O₅
• SMILES: COC1=C(C=C2C(=C1O)C(=O)C=C(O2)C3=CC=CC=C3)O
• Target: Others
• Solubility: DMSO : ≥ 32 mg/mL; 112.57 mM

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Baicalein 6-methyl ether | 6-Methoxybaicalein

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Gene Symbol

Others