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Oroxylin A
Catalog Number: orb1300223
| Catalog Number | orb1300223 |
|---|---|
| Category | Small Molecules |
| Description | Oroxylin A |
| Purity | 99.67% |
| MW | 284.26 |
| Biological Activity | 1. Oroxylin A (Baicalein 6-methyl ether) has various anti-tumor effects including apoptosis, cell cycle arrest, drug-resistant reversion. 2. Oroxylin A possesses abilities of inhibiting the ATRA-induced IL-6 production via modulation of LAP/LIP/CHOP in leukemia cell lines, which could providing a therapeutic strategy for RAS. 3. Oroxylin A inhibits UCP2s triggers the MPTP opening, and promotes the apoptosis in CaCo-2 cells; uncoupling protein 2 plays a key role in mitochondrial apoptotic pathway. 4. Oroxylin A inhibits N1ICD translocating to the nucleus and binding to epithelial-mesenchymal transition-related transcription factor Snail, thus suppressing the invasion and migration of MCF-7 cells. 5. Oroxylin A improves the sensitivity of K562/ADM cells by increasing apoptosis in leukemic cells and decreasing the expression of CXCR4 and PI3K/Akt/NF-κB pathway, and probably served as a most promising agent for CML treatment. |
| CAS Number | [480-11-5] |
| Formula | C16H12O5 |
| SMILES | COc1c(O)cc2oc(cc(=O)c2c1O)-c1ccccc1 |
| Storage | -20°C |
| Note | For research use only |
Oroxylin A 7-O-beta-D-glucuronide [orb1221544]
> 98% (HPLC)
36948-76-2
460.4
C22H20O11
1 g, 500 mg, 200 mg, 25 mg, 50 mg, 100 mg, 5 mg, 10 mgoroxylin A 7-O-β-d-glucuronide [orb1940901]
> 98% (HPLC)
36948-77-3
446.4
C22H22O10
5 mg, 10 mg, 1 g, 25 mg, 500 mg, 200 mg, 100 mg, 50 mgOroxylin A 7-O-β-D-glucuronide methyl ester [orb1943168]
98.00%
82475-02-3
474.41
C23H22O11
50 mg, 5 mgoroxylin A 7-O-β-d-glucuronide [orb1296970]
99.02%
[36948-77-3]
446.4
C22H22O10
5 mg, 50 mg, 25 mg, 10 mg, 1 mg, 1 ml x 10 mM (in DMSO)
