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Opaganib

SKU: orb1223659

Description

Opaganib (ABC-294640, ABC294640) is a selective, competitive and orally bioavailable sphingosine kinase-2 (SphK-2) inhibitor with IC50 of 60 uM, Ki of 9.8 uM; shows no activity against SphK-1 with IC50 of >100 uM; attenuates S1P formation in intact cells, suppresses the proliferation of a broad panel of tumor cell lines, and inhibits tumor cell migration concomitant with loss of microfilaments; demonstrates antitumor activity in adenocarcinoma xenograft models.Blood Cancer Phase 2 Clinical.

Images & Validation

Key Properties

CAS Number915385-81-8
MW380.916
Purity>98% (HPLC)
FormulaC23H25ClN2O
SMILESO=C([C@@]12C[C@]3(C4=CC=C(Cl)C=C4)C[C@@](C2)([H])C[C@](C3)([H])C1)NCC5=CC=NC=C5
TargetSphK
SolubilityDMSO: 71 mg/mL (186.4 mM); Ethanol: 27 mg/mL (70.9 mM); Water: <1 mg/mL ( < 1 mg/ml refers to the product slightly soluble or insoluble )

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

ABC294640 | ABC 294640 | ABC-294640

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Opaganib (orb1223659)

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Available Sizes

Select a size below

200 mg
500 mg
2 mg
$ 90.00
5 mg
$ 130.00
10 mg
$ 190.00
25 mg
$ 360.00
50 mg
$ 590.00
100 mg
$ 860.00