ONO-AE3-208

SKU: orb1218064

Description

ONO-AE3-208 is an EP4 antagonist. It suppresses cell migration, invasion, and metastasis of prostate cancer.

Key Properties

• CAS Number: 402473-54-5
• MW: 404.43
• Purity: >98% (HPLC)
• Formula: C₂₄H₂₁FN₂O₃
• SMILES: CC(C(Nc1c(CCCC(O)=O)ccc(C#N)c1)=O)c(c1ccccc11)ccc1F
• Target: Prostaglandin Receptor
• Solubility: DMSO:40 mg/mL (98.9 mM);Water: Insoluble

Bioactivity

• In Vivo:
  ONO-AE3-208 surpresses In vivo bone metastasis of PC3 cells in mice. The photon tumor burdens are significantly increased in a time-dependent manner in the control group in comparison with those in the ONO-AE3-208-treated group. The rate of metastasis formation is significantly higher in the former than in the latter. The median time of metastasis formation is 29 d in the ONO-AE3-208-treated animals as compared with 21 d in the controls.
• In Vitro:
  ONO-AE3-208 surpresses the in vitro cell invasion and migration in a dose-dependent manner without affecting cell proliferation. ONO-AE3-208 abolisheS CTGF in the presence of the EET synthesis inhibitor MS-PPOH. Arachidonic acid (AA) causeS dose-dependent dilation of the attached Af-Art, and this effect is blocked by ONO-AE3-208.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AE 3-208

Quick Database Links

Gene Symbol

Prostaglandin Receptor