ONO-AE3-208 sodium

SKU: orb2283775

Description

ONO-AE3-208 is an EP4 receptor antagonist with a Ki of 1.3 nM, exhibiting less potent activity against EP3, FP, and TP receptors (Ki values of 30, 790, and 2,400 nM, respectively), while showing no effect on other prostanoid receptors. In wild type mice, treatment with ONO-AE3-208, in conjunction with 3% dextran sodium sulfate, results in severe colitis characterized by epithelial loss, crypt damage, and inflammation, thereby mimicking the effects of EP4 deletion. Further, this compound has been utilized to investigate the role of EP4 signaling in various biological contexts, including immune and autoimmune responses, inflammation, and cancer.

Key Properties

• CAS Number: 2309931-05-1
• MW: 426.42
• Formula: C₂₄H₂₀FN₂O₃?Na
• SMILES: C(C(NC1=C(CCCC(O)=O)C=CC(C#N)=C1)=O)(C)C=2C3=C(C(F)=CC2)C=CC=C3.[Na]
• Target: Others

Storage & Handling

• Storage: -20°C
• Disclaimer: For research use only

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