Omodenbamab Antibody

SKU: orb1980337

Description

Omodenbamab (514-G3) is a humanized monoclonal antibody with high affinity (Kd = 0.0467 nM) that neutralizes Staphylococcus Protein A (SpA). It is used in research for studying S. aureus pathogenesis and has shown efficacy in preclinical models of bloodstream infection.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 2241724-48-9
• MW: 145.71 kDa
• Purity: 95.00%
• Target: Antibacterial

Bioactivity

• In Vivo:
  Methods: In a Balb/C mouse model of MRSA bacteremia, Omodenbamab was administered via intravenous injection at doses of 2.5 mg/mouse and 10 mg/mouse. Results: Omodenbamab increased survival in Balb/C mice within the MRSA bacteremia model.
• In Vitro:
  Methods: Human blood cells were treated with 10 μg/mL Omodenbamab and incubated for 30 minutes, 1.5 hours, and 2.5 hours to evaluate its effect on the opsonophagocytic activity against S. aureus. Results: Omodenbamab significantly enhanced the opsonophagocytic activity of human blood cells against S. aureus.

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Antibacterial