Omeprazole Sodium

SKU: orb1305954

Description

Omeprazole Sodium is a proton pump inhibitor that suppresses gastric acid secretion and also acts as a neutral sphingomyelinase (N-SMase) inhibitor to modulate exosome biogenesis. It competitively inhibits CYP2C19 and exhibits antibacterial properties against Gram-positive and Gram-negative bacteria, making it useful for gastrointestinal and exosome-related research in vitro.

Research Area

Cell Biology, Infectious Disease & Virology, Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 95510-70-6
• MW: 367.4
• Purity: 99.57% (May vary between batches)
• Formula: C₁₇H₁₈N₃NaO₃S
• SMILES: O=S(CC1=NC=C(C)C(OC)=C1C)C2=NC3=C([N-]2)C=C(OC)C=C3.[Na+]
• Target: Autophagy|||Cytochromes P450|||Proton pump|||Antibacterial
• Solubility: DMSO:120 mg/mL (326.62 mM);H2O:5.5 mg/mL (14.97 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (10.89 mM)

Bioactivity

• Target IC50:
  CYP2C19:2 to 6 μM(Ki)
• In Vivo:
  Omeprazole Sodium virtually eliminated intragastric acidity in all patients: the median 24 hour intragastric pH rose from 1.4 to 5.3 and the mean hourly hydrogen ion activity fell from 38.50 to 1.95 mmol(mEq)/1 (p less than 0.001)
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, H16868, H-16868, H 16868, inhibit, Omeprazole, Omeprazole Sodium, Autophagy, Bacterial, CYP2C19, Proton pump, Proton Pump, Protonpump, Phospholipase

Compound Identifiers

PubChem CID

12108541