Oligomycin

SKU: orb1819285

Description

Oligomycin is a macrolide antibiotic from Streptomyces, widely used to inhibit mitochondrial ATP synthase in both in vitro and in vivo studies of cellular metabolism, cancer research, and antifungal mechanisms.

Research Area

Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Infectious Disease & Virology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1404-19-9
• MW: 791.1(Oligomycin A) 805.1(Oligomycin B) 775.1(Oligomycin C)
• Purity: 98.00% (May vary between batches)
• Formula: C₄₅H₇₄O₁₁(Oligomycin A) C₄₅H₇₂O₁₂(Oligomycin B) C₄₅H₇₄O₁₀(Oligomycin C)
• SMILES: CC[C@@H]1CC[C@@H]2O[C@]3(CC[C@H](C)[C@H](C[C@@H](C)O)O3)[C@@H](C)[C@H](OC(=O)\C=C\[C@H](C)[C@@H](O)[C@H](C)C(=O)[C@H](C)[C@@H](O)[C@H](C)C(=O)[C@@H](C)[C@@H](O)[C@H](C)C\C=C\C=C\1)[C@@H]2C.CC[C@H]1CC[C@H]2O[C@@]3(CC[C@@H](C)[C@@H](C[C@H](C)O)O3)[C@H](C)[C@@H](OC(=O)\C=C\[C@@H](C)[C@H](O)[C@@H](C)C(=O)[C@@H](C)[C@H](O)[C@@H](C)C(=O)[C@@](C)(O)[C@H](O)[C@@H](C)C\C=C\C=C\1)[C@H]2C.CC[C@H]1CC[C@H]2O[C@]3(O[C@H](C[C@H](C)O)[C@H](C)CC3=O)[C@H](C)[C@@H](OC(=O)\C=C\[C@@H](C)[C@H](O)[C@@H](C)C(=O)[C@@H](C)[C@H](O)[C@@H](C)C(=O)[C@@](C)(O)[C@H](O)[C@@H](C)C\C=C\C=C\1)[C@H]2C
• Target: Antibiotic,OXPHOS,Antifungal,HIF,ATPase
• Solubility: DMSO:20 mg/mL

Bioactivity

• In Vitro:
  METHODS: The OCI-AML-1 cell line, OCI-AML-5 cell line and K562 cell line were treated with Oligomycin (0.025-500 nM) for 4 days to detect the inhibition of cell growth. RESULTS: Bleomycin hydrochloride inhibited the growth of the OCI-AML-1 cell line (IC50=0.05 nM), the OCI-AML-5 cell line (IC50=0.1 nM), and the K562 cell line (IC50=0.05 nM).

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

HIF-1α, Oligomycin, Oligomycin Complex

Compound Identifiers

PubChem CID

4591