Olaratumab Antibody

SKU: orb1980682

Description

Olaratumab (IMC-3G3) is a human IgG1 monoclonal antibody targeting PDGFRα. It exhibits antitumor activity and is utilized in research models for advanced soft tissue sarcoma, including in vitro cell-based assays and in vivo preclinical studies.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 1024603-93-7
• MW: 147.12 kDa
• Purity: 98.7% (SEC-HPLC)
• Target: PDGFR

Bioactivity

• In Vivo:
  IMC-3G3 ( Olaratumab ) ( i.p., 40 mg / kg, three times per week, 6 weeks ) In SKOV3-ip1 tumor-bearing mice, IMC-3G3 alone had no significant anti-tumor effect compared with the control group. In HeyA8 tumor-bearing mice, IMC-3G3 monotherapy showed a significant anti-tumor effect compared with the control group, with a tumor reduction rate of 62 % [ 1 ].
• In Vitro:
  In SKOV3-ip1 cells, IMC-3G3 (Olaratumab) at a concentration of 100 μg/mL for 72 hours blocked the phosphorylation of PDGFRα. Furthermore, the combination of IMC-3G3 with docetaxel notably induced apoptosis in SKOV3-ip1 and HeyA8 cell lines .

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PDGFRα, Olaratumab, LY3012207, LY-3012207, LY 3012207, IMC-3G3

Quick Database Links

Gene Symbol

PDGFR