Okanin

SKU: orb1297260

Description

Okanin is a bioactive small molecule demonstrating potent antioxidant activity, effectively inhibiting linoleic acid peroxidation and scavenging DPPH radicals. This makes it a valuable tool for research in oxidative stress, particularly for in vitro studies in biochemistry and pharmacology.

Research Area

Immunology & Inflammation, Signal Transduction

Key Properties

• CAS Number: 484-76-4
• MW: 288.25
• Purity: 99.64%
• Formula: C₁₅H₁₂O₆
• SMILES: Oc1ccc(\C=C\C(=O)c2ccc(O)c(O)c2O)cc1O
• Target: NF-κB,TLR
• Solubility: DMSO:135 mg/mL (468.34 mM);10% DMSO+90% Saline:2 mg/mL (6.94 mM)

Bioactivity

• In Vitro:
  Activity-guided fractionation of the EtOH extract of flowers of Bidens bipinnata L. have been furnished five flavonoids, sulfuretin(1), butein(2), 7,8,3 2,4 2-tetrahydroxyflavanone(3), maritimetin(4) and Okanin(5). All of the compounds showed significant activities on both linoleic acid peroxidation inhibition and DPPH radical scavenging effect. The evaluation for protective effect of isolated compounds against tacrine-induced cytotoxicity in human liver-derived Hep G2 cells was conducted. Compounds 1, 3, 4 and 5 showed significant protective effects with the EC50 values of 36.1±0.9, 23.3±0.7, 41.0±1.0 and 29.8±1.1 μM, respectively

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TLR, TLR4, Toll-like Receptor (TLR), inhibit, Inhibitor, Nrf2, NO Synthase, NFkB, NF-kB, NFκB, NF-κB, Okanin, Nuclear factor-kappaB, Nuclear factor-κB

Compound Identifiers

PubChem CID

5281294