Odanacatib

SKU: orb1301131

Description

Odanacatib

Research Area

Protein Biochemistry

Key Properties

• CAS Number: 603139-19-1
• MW: 525.56
• Purity: 99.53%
• Formula: C₂₅H₂₇F₄N₃O₃S
• SMILES: CC(C)(F)C[C@H](N[C@@H](c1ccc(cc1)-c1ccc(cc1)S(C)(=O)=O)C(F)(F)F)C(=O)NC1(CC1)C#N
• Target: Cysteine Protease
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+90% Corn Oil:3.3 mg/mL (6.28 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble);DMSO:93 mg/mL (176.95 mM)

Bioactivity

• Target IC50:
  Cathepsin K (rabbit):1 nM|Cathepsin K (human):0.2 nM
• In Vivo:
  Odanacatib exhibits inhibitory activity towards human cathepsin K IC50 0.2 nM) and rabbit cathepsin K IC50 1 nM). It also demonstrates effectiveness in human cell assays with an IC50 value of 5 nM.
• In Vitro:
  In rats, Odanacatib (10 mg/kg) exhibits efficient clearance (Cl: 2 ml kg-1 min-1), low volume of distribution (Vdss: 1.1 L kg-1), a half-life (T1/2) of 6 hours, and oral bioavailability (F) of 8%.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

CysteineProtease, Cysteine Protease, Cathepsin, Cathepsin K (human), Cathepsin K (rabbit), inhibit, MK 0822, MK0822, MK-0822, Odanacatib, Inhibitor

Compound Identifiers

PubChem CID

10152654