OD36 hydrochloride

SKU: orb1688611

Description

OD36 hydrochloride is a potent macrocyclic inhibitor of RIPK2 (IC50 = 5.3 nM) and ALK2 kinase (KD = 37 nM). It effectively blocks the ATP-binding site, antagonizing mutant ALK2 signaling and osteogenic differentiation, making it a valuable tool for studying fibrodysplasia ossificans progressiva (FOP) in cellular and animal models.

Research Area

Cardiovascular Research, Cell Biology, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 2387510-88-3
• MW: 367.23
• Purity: 99.85% (May vary between batches)
• Formula: C₁₆H₁₆Cl₂N₄O₂
• SMILES: Cl.ClC=1C=C2OCCOCCN=C3C=CN4N=CC(C(C1)=C2)=C4N3
• Target: ALK,TGF-beta/Smad,RIP kinase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

138991767