O-Desmethyl gefitinib

SKU: orb1741541

Description

O-Desmethyl gefitinib is a pharmacologically active metabolite of gefitinib, formed via CYP2D6 metabolism. It acts as an EGFR inhibitor with an IC50 of 36 nM in biochemical assays. This compound is used in research to study drug metabolism, EGFR signaling pathways, and resistance mechanisms in both cellular and animal models of cancer.

Research Area

Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 847949-49-9
• MW: 432.88
• Purity: 99.60% (May vary between batches)
• Formula: C₂₁H₂₂ClFN₄O₃
• SMILES: Oc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1
• Target: EGFR
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.62 mM);DMSO:27.5 mg/mL (63.53 mM)

Bioactivity

• Target IC50:
  EGFR:36 nM (IC50)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CYP2D6, HER1, Inhibitor, Gefitinib, human, Epidermal growth factor receptor, EGFR, ErbB-1, O Desmethyl gefitinib, ODesmethyl gefitinib, O-Desmethyl gefitinib, inhibit, plasma

Compound Identifiers

PubChem CID

135496227