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O-Desmethyl gefitinib

SKU: orb1219494

Description

O-Desmethyl gefitinib inhibits EGFR (IC50: 36 nM in subcellular assays). In human plasma, O-Desmethyl gefitinib is an active metabolite of Gefitinib. The formation of O-desmethyl gefitinib is dependent on the CYP2D6 activity.

Images & Validation

Key Properties

CAS Number847949-49-9
MW432.88
Purity>98% (HPLC)
FormulaC21H22ClFN4O3
SMILESOc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1
TargetEGFR
SolubilityIn Vitro: DMSO : 100 mg/mL (231.01 mM)

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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O-Desmethyl gefitinib (orb1219494)

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200 mg
500 mg
5 mg
$ 180.00
10 mg
$ 260.00
25 mg
$ 490.00
50 mg
$ 770.00
100 mg
$ 1,080.00