O-Desmethyl gefitinib

SKU: orb1219494

Description

O-Desmethyl gefitinib inhibits EGFR (IC50: 36 nM in subcellular assays). In human plasma, O-Desmethyl gefitinib is an active metabolite of Gefitinib. The formation of O-desmethyl gefitinib is dependent on the CYP2D6 activity.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 847949-49-9
• MW: 432.88
• Purity: >98% (HPLC)
• Formula: C₂₁H₂₂ClFN₄O₃
• SMILES: Oc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1
• Target: EGFR
• Solubility: In Vitro: DMSO : 100 mg/mL (231.01 mM)

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

EGFR