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NVP-TAE 684

SKU: orb1224051

Description

A highly potent and selective, orally available ALK inhibitor with IC50 of 3 nM in cell-free assays; exhibits no significant cross-reactivity against other kinases; blocks the growth of ALCL-derived and ALK-dependent cell lines with IC50 2-10 nM, inhibits phosphorylation of NPM-ALK and its downstream effectors and subsequent induction of apoptosis and cell cycle arrest; suppresses lymphomagenesis in in vivo models.Blood Cancer Discontinued.

Images & Validation

Key Properties

CAS Number761439-42-3
MW614.2017
Purity>98% (HPLC)
FormulaC30H40ClN7O3S
SMILESCN1CCN(C2CCN(C3=CC=C(NC4=NC=C(Cl)C(NC5=CC=CC=C5S(=O)(C(C)C)=O)=N4)C(OC)=C3)CC2)CC1
TargetALK
Solubility10 mM in DMSO

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

TAE-684 | TAE684 | NVP TAE684

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NVP-TAE 684 (orb1224051)

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Available Sizes

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200 mg
500 mg
2 mg
$ 100.00
5 mg
$ 140.00
10 mg
$ 190.00
25 mg
$ 320.00
50 mg
$ 470.00
100 mg
$ 650.00